{"id":4761,"date":"2019-02-22T14:21:53","date_gmt":"2019-02-22T13:21:53","guid":{"rendered":"https:\/\/maedchen-frau-dame.de\/?page_id=4761"},"modified":"2019-02-22T14:34:57","modified_gmt":"2019-02-22T13:34:57","slug":"die-bewegte-frau-3-2-3-2","status":"publish","type":"page","link":"https:\/\/maedchen-frau-dame.de\/?page_id=4761","title":{"rendered":"Brustkrebs: Test kann Chemotherapie ersparen"},"content":{"rendered":"<p>[vc_row css=&#8220;.vc_custom_1491321293893{margin-right: 24px !important;margin-left: 24px !important;}&#8220;][vc_column width=&#8220;2\/3&#8243; css=&#8220;.vc_custom_1550819706297{margin-right: 10px !important;margin-left: 10px !important;}&#8220;][vc_single_image image=&#8220;4763&#8243; img_size=&#8220;large&#8220; alignment=&#8220;center&#8220; css_animation=&#8220;appear&#8220;][vc_column_text css=&#8220;.vc_custom_1550838316095{margin-bottom: 2px !important;border-bottom-width: 2px !important;padding-bottom: 2px !important;}&#8220;]<\/p>\n<p style=\"text-align: left;\">Werbebeitrag Interview<\/p>\n<p>[\/vc_column_text]<div class=\"wpb_content_element  vc_custom_1550841431204\"><style type=\"text\/css\" scoped><\/style><header id=\"ut_header_69ef3b1ac8ba0\" class=\"section-header pt-style-7 header-left\"><h2 class=\"section-title\"><span>Brustkrebs: Test kann Chemotherapie ersparen<\/span><\/h2><\/header><\/div>[vc_column_text]<\/p>\n<p style=\"text-align: left;\"><strong>Welche Brustkrebspatientinnen profitieren von einer Chemotherapie und welche nicht? Das war die Ausgangsfrage der weltweit gr\u00f6\u00dften Brustkrebsstudie bisher. An dieser Studie mit Namen \u201eTAILORx\u201c nahmen mehr als 10.000 Frauen teil. Die Ergebnisse haben die Forscher im vergangenen Jahr 2018 vorgestellt, verbunden mit einer sehr guten Nachricht f\u00fcr viele Patientinnen. Prof. Dr. Ulrike Nitz, Leiterin des Brustzentrums Niederrhein in M\u00f6nchengladbach, erkl\u00e4rt warum. <\/strong><\/p>\n<h3>Um welches medizinische Problem ging es in der TAILORx-Studie?<\/h3>\n<p>Brustkrebs kann von Patientin zu Patientin sehr unterschiedlich sein. Jede Patientin sollte daher die f\u00fcr sie passende Behandlung bekommen. Bisher haben wir uns f\u00fcr die Therapieentscheidung an klassischen Prognosekriterien orientiert, wie zum Beispiel der Tumorgr\u00f6\u00dfe oder der Anzahl der betroffenen Lymphknoten. Diese Kriterien allein sind aber in einigen F\u00e4llen wenig genau, insbesondere wenn Frauen mit hormonempfindlichen Tumoren betroffen sind. Und das sind immerhin um die\u00a070\u00a0% der Brustkrebsf\u00e4lle. Hormonempfindliche Tumoren sind prognostisch oft schwerer einzusch\u00e4tzen. Im Zweifelsfall erhielt die Patientin sicherheitshalber eine Chemotherapie \u2013 h\u00e4ufig unn\u00f6tigerweise, wie sich herausstellte.<\/p>\n<h3>Wie gingen die Wissenschaftler in der Studie vor?<\/h3>\n<p>In TAILORx haben \u00c4rzte ihre Therapieentscheidung bei hormonempfindlichem Brustkrebs ohne Lymphknotenbefall nach den Ergebnissen eines Genexpressionstests, des Oncotype DX Breast Recurrence Score\u00ae Tests, getroffen. Der Test liefert einen Wert zwischen 0 und 100, an dem die \u00c4rztin oder der Arzt das Wiedererkrankungsrisiko ablesen kann. Je niedriger der Wert, desto niedriger das Risiko. Patientinnen mit einem niedrigen Risiko bekamen nur eine Antihormontherapie, Patientinnen mit hohen Werten zus\u00e4tzlich eine Chemotherapie. Bei 6.711 Frauen, also bei mehr als zwei Drittel, hat der Oncotype DX Test einen Recurrence Score\u00ae von RS 12 bis 25 ergeben. Der Nutzen einer Chemotherapie war bei diesen Patientinnen anhand der bislang vorliegenden Daten unklar. Daher erhielt diese Gruppe in der Studie nach dem Zufallsprinzip entweder nur eine Antihormontherapie oder Antihormon- plus Chemotherapie.<\/p>\n<h3>Was war das Ergebnis?<\/h3>\n<p>Die Ergebnisse in dieser Patientengruppe sind mit einer \u00dcberlebensrate von knapp 94\u00a0% nach neun Jahren hervorragend \u2013 93,9\u00a0% ohne Chemo, 93,8\u00a0% mit Chemo. Krankheitsfrei blieben zu diesem Zeitpunkt 83,3\u00a0% ohne Chemo bzw. 84,4\u00a0% mit Chemo. Die Chemo hatte also bei Testergebnissen im mittleren Bereich keinen zus\u00e4tzlichen Nutzen.<\/p>\n<p>Bei Testergebnissen im Hochrisiko-Bereich liegen die \u00dcberlebensraten im Rahmen des Erwarteten. Trotz Chemotherapie sind hier nach neun Jahren 13\u00a0% der Frauen wiedererkrankt.<\/p>\n<h3>Welche Bedeutung haben diese Ergebnisse f\u00fcr<br \/>\nBrustkrebspatientinnen?<\/h3>\n<p>Mithilfe des Oncotype DX k\u00f6nnen wir klarer entscheiden, bei welcher Patientin eine Chemotherapie angebracht ist und bei welcher nicht. Patientinnen mit niedrigen und mittleren Oncotype DX Werten haben eine ausgezeichnete Prognose und bed\u00fcrfen definitiv keiner Chemotherapie. In Zahlen hei\u00dft das: Wir k\u00f6nnen der \u00fcberwiegenden Mehrheit der Frauen mit fr\u00fchem hormonsensiblem Brustkrebs die Entscheidung gegen eine Chemotherapie anbieten \u2013 ohne den Behandlungserfolg zu gef\u00e4hrden. In Deutschland betrifft das pro Jahr bis zu 25.000 Frauen. Ein Meilenstein in der Geschichte der Brustkrebstherapie!<\/p>\n<p>Im Tumorboard diskutierten die \u00c4rzte von Kirsten M. ihren Fall genauer und kamen nicht zu einem eindeutigen Ergebnis. \u201eEs war unklar, ob mir eine Chemo weiterhelfen w\u00fcrde. Mein Arzt erz\u00e4hlte mir vom Oncotype DX. Mit diesem Test k\u00f6nne sehr genau bestimmt werden, ob ich eine Chemo ben\u00f6tige oder nicht.\u201c Kirsten M. lie\u00df den Test durchf\u00fchren. Die Aussicht auf eine Chemotherapie aber belastete sie: \u201eDie Chemo l\u00f6ste bei mir Angst, Aggression und Ablehnung aus.\u201c Als der Arzt das Ergebnis hatte, rief er Kirsten M. auf dem Handy an. \u201eMein Arzt nannte mir nur die Zahl 17, also meinen Recurrence Score\u00ae. Damit war f\u00fcr mich alles klar: Ich brauchte keine Chemo. Das machte mich wahnsinnig gl\u00fccklich, war f\u00fcr mich wie ein zweiter Geburtstag. Mir war augenblicklich klar, dass mir s\u00e4mtliche Nebenwirkungen und Langzeitsch\u00e4den einer Chemotherapie erspart werden konnten.\u201c<\/p>\n<p><a href=\"http:\/\/www.meine-therapieentscheidung.de\" target=\"_blank\" rel=\"noopener\">www.meine-therapieentscheidung.de<\/a><\/p>\n<p>[\/vc_column_text][vc_empty_space][vc_btn title=&#8220;zur\u00fcck&#8220; style=&#8220;custom&#8220; custom_background=&#8220;#aa3458&#8243; custom_text=&#8220;#ffffff&#8220; size=&#8220;lg&#8220; align=&#8220;left&#8220; css_animation=&#8220;appear&#8220; custom_onclick=&#8220;true&#8220; link=&#8220;url:http%3A%2F%2Fwww.maedchen-frau-dame.de|||&#8220;][vc_row_inner disable_element=&#8220;yes&#8220;][vc_column_inner][vc_single_image image=&#8220;4737&#8243; img_size=&#8220;large&#8220;][\/vc_column_inner][\/vc_row_inner][\/vc_column][vc_column width=&#8220;1\/3&#8243; css=&#8220;.vc_custom_1491321626331{margin-right: 24px !important;margin-left: 24px !important;}&#8220; offset=&#8220;vc_hidden-xs&#8220;][vc_empty_space height=&#8220;00px&#8220;][vc_btn title=&#8220;zur\u00fcck&#8220; style=&#8220;custom&#8220; custom_background=&#8220;#aa3458&#8243; custom_text=&#8220;#ffffff&#8220; size=&#8220;lg&#8220; align=&#8220;right&#8220; css_animation=&#8220;appear&#8220; custom_onclick=&#8220;true&#8220; link=&#8220;url:http%3A%2F%2Fwww.maedchen-frau-dame.de|||&#8220;][vc_empty_space height=&#8220;190px&#8220;][vc_row_inner][vc_column_inner][vc_column_text css=&#8220;.vc_custom_1550841618421{padding-top: 15px !important;padding-right: 15px !important;padding-bottom: 15px !important;padding-left: 15px !important;background-color: #e0e0e0 !important;border-radius: 2px !important;}&#8220;]<strong>Kontakt<\/strong><\/p>\n<p>Genomic Health Deutschland GmbH<br \/>\nErna-Scheffler Strasse 1a<br \/>\n51103 K\u00f6ln<\/p>\n<p><a href=\"mailto:kundendienst@genomichealth.com\">kundendienst@genomichealth.com<\/a><br \/>\n<a href=\"https:\/\/www.meine-therapieentscheidung.de\/de-DE\/\" target=\"_blank\" rel=\"noopener\">www.meine-therapieentscheidung.de<\/a><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[vc_row css=&#8220;.vc_custom_1491321293893{margin-right: 24px !important;margin-left: 24px !important;}&#8220;][vc_column width=&#8220;2\/3&#8243; css=&#8220;.vc_custom_1550819706297{margin-right: 10px !important;margin-left: 10px !important;}&#8220;][vc_single_image image=&#8220;4763&#8243; img_size=&#8220;large&#8220; alignment=&#8220;center&#8220; css_animation=&#8220;appear&#8220;][vc_column_text css=&#8220;.vc_custom_1550838316095{margin-bottom: 2px !important;border-bottom-width: 2px !important;padding-bottom: 2px !important;}&#8220;] Werbebeitrag Interview [\/vc_column_text][vc_column_text] Welche Brustkrebspatientinnen profitieren von einer Chemotherapie und welche nicht? Das war die Ausgangsfrage der weltweit gr\u00f6\u00dften Brustkrebsstudie bisher. An dieser Studie mit Namen \u201eTAILORx\u201c nahmen mehr als 10.000 Frauen [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-4761","page","type-page","status-publish","hentry"],"rankMath":{"parentDomain":"maedchen-frau-dame.de","noFollowDomains":[],"noFollowExcludeDomains":[],"noFollowExternalLinks":false,"featuredImageNotice":"Das angezeigte Beitragsbild sollte mindestens 200x200 px gro\u00df sein, damit Facebook und andere Social-Media-Websites es 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